무모쥐의 피부화상에 대한 실크피브로인 필름 피복제의 치유 효능

최영희; 김민규; 안동현; 홍수희; 이재용; 김해성; 김흥철; 남상용; 임건빈

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자료유형: 학술저널

저자정보: 최영희 (한림대학교) 김민규 (한림대학교) 안동현 (한림대학교) 홍수희 (한림대학교) 이재용 (한림대학교) 김해성 (한림대학교) 김흥철 (한림대학교) 남상용 (삼육대학교) 임건빈 (화인코)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.79 No.6

발행연도: 2010.12

수록면: 421 - 427 (7page)

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연구주제

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연구배경

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연구방법

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연구결과

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Purpose: The aim of this study was to examine the effects of silk fibroin film on wound healing of cutaneous burn in hairless mice by using microscopic findings and stem cell markers (nestin, cytokeratin 15) and ki-67 proliferation marker.
Methods: Each mouse received two burns at the dorsal area by applying a metal rod heated with boiling water. Burn wound sites were dressed with Silk Fibroin Film and duoderm (SF group), Aquacel hydrofiber and duoderm (AC group) and duoderm only (Control group). All groups were covered externally with duodermas adhesive bands. Those mice were sacrificed at zero, two, seven, fourteen and twenty one days after burn. Histological findings and immunohistochemical staining for stem cell markers were observed.
Results: In SF group, inflammatory cell infiltration, formation of granulation tissue and inflammatory foci are greater than in AC and control group. Those factors appear to enhance mesenchymal stem cell markers such as nestin. Finally mesenchymal tissue regeneration was enhanced. In addition, the length of ki-67 expressed re-generating epithelium, which appeared to be associated with epithelial regeneration, was the longest in SF group.
Conclusion: The results show that the wound healing effect of SF is the best among other treatment materials including AC in the experimental group and duoderm in the control group through mesenchymal regeneration and epithelial regeneration which are essential factors for wound healing.

#Hairless mice #Silk fibroin film #Burn #Wound healing #Stem cell #무모쥐 #실크피브로인 #화상 #창상치유 #줄기세포

참고문헌 (18)

참고문헌 신청

1. [단행본] - Korean Research Group for Wound Care / 2002 / Advances in Wound Care. 1st ed / Korea Medical Book Publisher : 11 ~ 19

3. [학술지(정기간행물)] - Zhu H / 2008 / Effects of nitric oxide on skin burn wound healing / J Burn Care Res 29 : 804 ~ 814

4. [학술지(정기간행물)] - Yoon HJ / 2007 / The effect of vitamin C and E on the expression of the cutaneous basement membrane components / Korean J Investig Dermatol 14 : 87 ~ 98

5. [학술지(정기간행물)] - Freddi G / 1999 / Structure and physical properties of silk fibroin/polyacrylamide blend films / J Appl Polym Sci 71 : 1563 ~ 1571

6. [학술지(정기간행물)] - Kato N / 1998 / Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity / Biosci Biotechnol Biochem 62 : 145 ~ 147

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최영희

소속기관 한림대학교

주요연구분야 의약학 > 임상의학 > 일반 외과학 의약학 > 임상의학 > 비뇨기과학

논문수 17 이용수 1,177

Min Gyu Kim

소속기관 Hanyang University School of Medicine

주요연구분야 사회과학 > 경제학 의약학 > 임상의학 > 일반 외과학

논문수 23 이용수 1,278

안동현

소속기관 한림대학교