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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 51 - 57 (7page)
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초록· 키워드
오류제보하기
Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.
목차
VACCINES
NEED FOR ADJUVANTS
ADJUVANTS APPROVED FOR HUMAN VACCINES
ADJUVANTS IN CLINICAL DEVELOPMENT
CONCLUSIONS AND PERSPECTIVES
REFERENCES
참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Fauci, A. S. / 2001 / Infectious diseases: considerations for the 21st century / Clin. Infect. Dis 32 : 675 ~ 685
2. [학술지(정기간행물)] - Leroux-Roels, G. / 2010 / Unmet needs in modern vaccinology:adjuvants to improve the immune response / Vaccine 28 (Suppl 3) : C25 ~ C36
3. [학술지(정기간행물)] - Chan, E. H. / 2010 / Global capacity for emerging infectious disease detection / Proc. Natl. Acad. Sci. U. S. A 107 : 21701 ~ 21706
4. [학술지(정기간행물)] - WHO Ebola Response Team / 2014 / Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections / N. Engl. J. Med 371 : 1481 ~ 1495
5. [학술지(정기간행물)] - Riese, P. / 2013 / Vaccine adjuvants: key tools for innovative vaccine design / Curr. Top. Med. Chem 13 : 2562 ~ 2580
2. [학술지(정기간행물)] - Leroux-Roels, G. / 2010 / Unmet needs in modern vaccinology:adjuvants to improve the immune response / Vaccine 28 (Suppl 3) : C25 ~ C36
3. [학술지(정기간행물)] - Chan, E. H. / 2010 / Global capacity for emerging infectious disease detection / Proc. Natl. Acad. Sci. U. S. A 107 : 21701 ~ 21706
4. [학술지(정기간행물)] - WHO Ebola Response Team / 2014 / Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections / N. Engl. J. Med 371 : 1481 ~ 1495
5. [학술지(정기간행물)] - Riese, P. / 2013 / Vaccine adjuvants: key tools for innovative vaccine design / Curr. Top. Med. Chem 13 : 2562 ~ 2580
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UCI(KEPA) : I410-ECN-0101-2016-511-001746280