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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Objectives: As interests in the beauty of skin is growing continuously, more people are focusing on white and clean skin. Melanin is the major factor that determines skin color. The abnormal concentration of melanin causes various skin diseases such as vitiligo, freckles, and melasma. This study investigated the inhibitory effect of Eriobotryae Folium extracts (EF) with phreatic water (PW) on the melanin synthesis.
Methods: The effect of EF on melanin synthesis was evaluated by using mouse melanoma cells (B16F10). To define the mechanisms, real-time PCR and western blot were used. We also evaluated the inhibitory effects of EF and PW on melanin synthesis by using HRM-2 melanin-possessing hairless mice. After UVB irradiation, melanin differences between the skin parts that were treated and untreated with EF and PW. Levels of mRNA were measured by real-time quantitative PCR and histological analysis of the dorsal skin was conducted by hematoxylin and eosin staining.
Results: EF inhibited various mechanisms of melanogenesis, and the effect was increased when combined with PW. In vitro experiments have shown that EF inhibited the expressions of tyrosinase related protein-1 (TRP-1) mRNA, tyrosinase mRNA, microphthalmia-associated transcription factor (MITF) mRNA and the tyrosinase inhibitory activation, but it stimulated the extracellular regulated kinase (ERK) mRNA expression. In vivo experiments have shown that EF prevented melanogenesis in the mice dorsal skin and inhibited TRP-1 mRNA expression. Also these effects were increased when combined with PW.
Conclusions: EF and PW might be a new and effective treatment for whitening and treating pigmentation of skin.
Methods: The effect of EF on melanin synthesis was evaluated by using mouse melanoma cells (B16F10). To define the mechanisms, real-time PCR and western blot were used. We also evaluated the inhibitory effects of EF and PW on melanin synthesis by using HRM-2 melanin-possessing hairless mice. After UVB irradiation, melanin differences between the skin parts that were treated and untreated with EF and PW. Levels of mRNA were measured by real-time quantitative PCR and histological analysis of the dorsal skin was conducted by hematoxylin and eosin staining.
Results: EF inhibited various mechanisms of melanogenesis, and the effect was increased when combined with PW. In vitro experiments have shown that EF inhibited the expressions of tyrosinase related protein-1 (TRP-1) mRNA, tyrosinase mRNA, microphthalmia-associated transcription factor (MITF) mRNA and the tyrosinase inhibitory activation, but it stimulated the extracellular regulated kinase (ERK) mRNA expression. In vivo experiments have shown that EF prevented melanogenesis in the mice dorsal skin and inhibited TRP-1 mRNA expression. Also these effects were increased when combined with PW.
Conclusions: EF and PW might be a new and effective treatment for whitening and treating pigmentation of skin.
목차
Introduction
Methods
Results
Discussion
Conclusion
Reference
참고문헌 (30)
참고문헌 신청
Do EJ, Lee JS, Park HJ, Ha ID, Kim YC, Kim MR. The Efficacy of Ampule Containing Herbal Extract for Improving Skin Wrinkles in Women. The Korean Journal of Oriental Medical Prescription. 2009;17(2):111-121.
Lim SJ. Skin-Whitening Awareness and Whitening -Care Behavior in Women. Jounal of The Korean Society of cosmetology. 2009;15(2): 463-474.
Prota G. Melanins and Melanogenesis. Academic Press. 1992;208-209.
Lee HH. Current Trends on the Development of Whitening Products. Journal of the society of cosmetic scientists of Korea. 1997;23(1):43-56.
Yeo MG. Compilation Committee of Dermatology Textbooks. Dermatology. Seoul:2001:1-9, 133, 409-12, 553-555.
Lee HH. Current Trends on the Development of Whitening Products. Journal of the society of cosmetic scientists of Korea. 1997;23(1):43-56.
Yeo MG. Compilation Committee of Dermatology Textbooks. Dermatology. Seoul:2001:1-9, 133, 409-12, 553-555.
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