지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- Korean Society for Precision Engineering Journal of the Korean Society for Precision Engineering Journal of the Korean Society for Precision Engineering Vol.35 No.9
- 발행연도
- 2018.9
- 수록면
- 835 - 840 (6page)
- DOI
- 10.7736/KSPE.2018.35.9.835
이용수
초록· 키워드
오류제보하기
A programmable drug delivery system can control the release rate of a drug. It can minimize side effects while maximizing therapeutic effects. In this research, we investigated the feasibility of producing a programmable drug delivery system using 3D printing technology. A capsule with a micro-orifice and a drug-laden hydrogel was designed. The designed system was then fabricated by the printing process using polycaprolactone and hydrogel. The printed drug delivery system was immersed in PBS at 37°C and the number of molecules released was measured thorough colorimetric analysis. The effect of diameter and length of the micro-orifice and concentration of the hydrogel on drug release characteristics was then determined. The initial burst release rate was found to be increased with increasing orifice size. Increasing the length of the orifice linearly delayed the start time of drug release. At length of 600 μm and 1,200 μm, drug release was initiated after 36 h and 72 h for, respectively. When the concentration of hydrogel was increased, drug release rate tended to decrease. These results successfully confirmed that a drug delivery system with controlled release rate and initiation time could be manufactured using 3D printing technology.
목차
1. 서론
2. 3D 프린팅 시스템을 이용한 약물 전달용 캡슐 제작
3. 약물 방출 특성 측정 및 분석
4. 결론
REFERENCES
참고문헌 (17)
참고문헌 신청
Allen, T. M. and Cullis, P. R., “Drug Delivery Systems: Entering the Mainstream,” Science, Vol. 303, No. 5665, pp. 1818-1822, 2004.
Brem, H., “Polymers to Treat Brain Tumours,” Biomaterials, Vol. 11, No. 9, pp. 699-701, 1990.
Fung, L. K. and Saltzman, W. M., “Polymeric Implants for Cancer Chemotherapy,” Advanced Drug Delivery Reviews, Vol. 26, Nos. 2-3, pp. 209-230, 1997.
Zema, L., Melocchi, A., Maroni, A., and Gazzaniga, A., “Three- Dimensional Printing of Medicinal Products and the Challenge of Personalized Therapy,” Journal of Pharmaceutical Sciences, Vol. 106, No. 7, pp. 1697-1705, 2017.
Kyobula, M., Adedeji, A., Alexander, M. R., Saleh, E., Wildman, R., et al., “3D Inkjet Printing of Tablets Exploiting Bespoke Complex Geometries for Controlled and Tuneable Drug Release,” Journal of Controlled Release, Vol. 261, pp. 207-215, 2017.
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