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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 520 - 525 (6page)
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초록· 키워드
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We investigated the effects of two antimicrobial peptides (AMPs) isolated from Scolopendra subspinipes mutilans on neutrophil activity. Stimulation of mouse neutrophils with the two AMPs elicited chemotactic migration of the cells in a pertussis toxin-sensitive manner. The two AMPs also stimulated activation of ERK and Akt, which contribute to chemotactic migration of neutrophils. We found that AMP-stimulated neutrophil chemotaxis was blocked by a formyl peptide receptor (FPR) 1 antagonist (cyclosporin H); moreover the two AMPs stimulated the chemotactic migration of FPR1-expressing RBL-2H3 cells but not of vector-expressing RBL-2H3 cells. We also found that the two AMPs stimulate neutrophil migration in vivo, and that this effect is blocked in FPR1-deficient mice. Taken together, our results suggest that the two AMPs stimulate neutrophils, leading to chemotactic migration through FPR1, and the two AMPs will be useful for the study of FPR1 signaling and neutrophil activation.
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참고문헌 (34)
참고문헌 신청
Kolaczkowska E / 2013 / Neutrophil recruitment and function in health and inflammation / Nat Rev Immunol 13:159~175
Heit B / 2008 / PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils / Nat Immunol 9:743~752
Wright HL / 2010 / Neutrophil function in inflammation and inflammatory diseases / Rheumatology 49:1618~1631
Craig A / 2009 / Neutrophil recruitment to the lungs during bacterial pneumonia / Infect Immun 77:568~575
Fu H / 2006 / Ligand recognition and activation of formyl peptide receptors in neutrophils / J Leukoc Biol 79:247~256
Heit B / 2008 / PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils / Nat Immunol 9:743~752
Wright HL / 2010 / Neutrophil function in inflammation and inflammatory diseases / Rheumatology 49:1618~1631
Craig A / 2009 / Neutrophil recruitment to the lungs during bacterial pneumonia / Infect Immun 77:568~575
Fu H / 2006 / Ligand recognition and activation of formyl peptide receptors in neutrophils / J Leukoc Biol 79:247~256
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