지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 401 - 410 (10page)
이용수
초록· 키워드
오류제보하기
The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins. Recent structural and functional studies have demonstrated that PDI members not only play an essential role in the proteostasis in the ER but also exert diverse effects in numerous human disorders including cancer and neurodegenerative diseases. Increasing evidence suggests that PDI is actively involved in the proliferation, survival, and metastasis of several types of cancer cells. Although the molecular mechanism by which PDI contributes to tumorigenesis and metastasis remains to be understood, PDI is now emerging as a new therapeutic target for cancer treatment. In fact, several attempts have been made to develop PDI inhibitors as anti-cancer drugs. In this review, we discuss the properties and diverse functions of human PDI proteins and focus on recent findings regarding their roles in the state of diseases including cancer and neurodegeneration.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alanen HI / 2003 / Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member / J Biol Chem 278 : 28912 ~ 28920
Alanen HI / 2006 / ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member Interacts with ERp57 / J Biol Chem 281 : 33727 ~
Appenzeller-Herzog C / 2008 / The human PDI family: Versatility packed into a single fold / Biochim Biophys Acta 1783 : 535 ~ 548
Bosnjak I / 2014 / Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank / Prot Eng Des Selec 27 : 65 ~ 72
Brychtova V / 2011 / Anterior gradient 2: a novel player in tumor cell biology / Cancer Lett 304 : 1 ~ 7
Alanen HI / 2006 / ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member Interacts with ERp57 / J Biol Chem 281 : 33727 ~
Appenzeller-Herzog C / 2008 / The human PDI family: Versatility packed into a single fold / Biochim Biophys Acta 1783 : 535 ~ 548
Bosnjak I / 2014 / Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank / Prot Eng Des Selec 27 : 65 ~ 72
Brychtova V / 2011 / Anterior gradient 2: a novel player in tumor cell biology / Cancer Lett 304 : 1 ~ 7
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protein disulfide isomerase in cardiovascular disease
Experimental and Molecular Medicine
2020 .01
-
PDI-based small molecule acceptors for efficient fullerene-free organic solar cell : A study on the effect of the molecular arrangement of PDI molecules on Power Conversion Efficiency
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
적정 덧씌우기 시기 결정을 위한 PDI(Pavement Damage Index) 개발에 관한 연구
대한토목학회 학술대회
2023 .10
-
A study on handwritten parcel delivery invoice understanding model
Journal of Advanced Marine Engineering and Technology (JAMET)
2022 .12
-
이동형 위성통신시스템에서의 PDI 타이밍 동기기술의 프리엠블 길이별 성능 비교
한국항공우주학회 학술발표회 초록집
2017 .11
-
Defect-Covered Perovskite Optoelectronics via Tailoring PDI-derivative Interface for Optimized Current Generation under Various Illumination
한국고분자학회 학술대회 연구논문 초록집
2023 .04
-
Acceleration Charge Extraction via PDI-Derivative with Aliphatic Amine for Sensitive and Fast Photodetection
한국고분자학회 학술대회 연구논문 초록집
2022 .10
-
Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Experimental and Molecular Medicine
2024 .01
-
Non-fullerene Based N-type PDI (Perylene Diimides)-derivative Interlayer Engineering for Efficient Perovskite Photodetection
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
Synthesis of Poly(disulfide)s with Narrow Molecular Weight Distributions via Lactone Ring-opening Polymerization
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Microsensor for Cancer Detection and MEMS Actuator for Cancer Therapy
Transactions on Electrical and Electronic Materials
2023 .02
-
노출평가를 위한 BEI의 근거 - CARBON DISULFIDE(5)
산업보건
2015 .01
-
암 생존자의 질병관련 특성과 암 대처가 외상 후 성장에 미치는 영향
보건정보통계학회지
2015 .01
-
Emerging roles of exosomes in cancer invasion and metastasis
BMB Reports
2016 .01
-
High-refractive Index Transparent Polyurethane from the Chain Extender Bis-(3-hydroxyphenyl) Disulfide
한국고분자학회 학술대회 연구논문 초록집
2018 .10
-
Approach to Soluble Expression of Recombinant Lignin Peroxidase in Escherichia coli by Removing Disulfide Bond
한국생물공학회 학술대회
2021 .10
-
Protein nanoparticles directed cancer imaging and therapy
Nano Convergence
2022 .01
-
DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancer
Experimental and Molecular Medicine
2023 .05
-
3D printing of a patient-specific brain cancer-on-a-chip
대한기계학회 춘추학술대회
2017 .11
-
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
Experimental and Molecular Medicine
2021 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0