지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 99 - 104 (6page)
이용수
초록· 키워드
오류제보하기
The nuclear non-histone protein high mobility group box (HMGB) 1 is known to having an inhibitory effect on the repair of DNA damaged by the antitumor drug cisplatin in vitro. To investigate the role of HMGB1 in living cells, we studied the DNA repair of cisplatin damages in mouse fibroblast cell line, NIH-3T3. We evaluated the effect of the post-synthetic acetylation and C-terminal domain of the protein by overexpression of the parental and mutant GFP fused forms of HMGB1. The results revealed that HMGB1 had also an inhibitory effect on the repair of cisplatin damaged DNA in vivo. The silencing of HMGB1 in NIH-3T3 cells increased the cellular DNA repair potential. The increased levels of repair synthesis could be “rescued” and returned to less than normal levels if the knockdown cells were transfected with plasmids encoding HMGB1 and HMGB1 K2A. In this case, the truncated form of HMGB1 also exhibited a slight inhibitory effect.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Goodwin GH / 1973 / A new group of chromatin-associated proteins with a high content of acidic, basic amino acids / Eur J Biochem 38:14~19
Reeves R / 2005 / Role of high mobility group(HMG)chromatin proteins in DNA repair / DNA Repair 4:926~938
Pasheva EA / 1998 / Preferential binding of high mobility group 1 protein to UV damaged DNA / J Biol Chem 273:24730~24736
Pil PM / 1992 / Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin / Science 256:234~237
Hughes EN / 1992 / Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1, 2 / J Biol Chem 267:13520~13527
Reeves R / 2005 / Role of high mobility group(HMG)chromatin proteins in DNA repair / DNA Repair 4:926~938
Pasheva EA / 1998 / Preferential binding of high mobility group 1 protein to UV damaged DNA / J Biol Chem 273:24730~24736
Pil PM / 1992 / Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin / Science 256:234~237
Hughes EN / 1992 / Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1, 2 / J Biol Chem 267:13520~13527
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis
BMB Reports
2017 .01
-
Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses
BMB Reports
2016 .01
-
Backbone assignment of HMGB1 A-box and molecular interaction with Hoxc9DBD studied by paramagnetic probe
Journal of the Korean Magnetic Resonance Society
2021 .01
-
Ultrasound-Responsive Nanobubbles for Releasing Intact HMGB1 in Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Ultrasound-responsive Nanoparticles for Releasing Intact HMGB1 in Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
29-kDa FN-f inhibited autophagy through modulating localization of HMGB1 in human articular chondrocytes
BMB Reports
2018 .01
-
Modulation of HMGB1 Activity for Successful Outcome of Islet Transplantation
한국생물공학회 학술대회
2015 .10
-
Modulation of HMGB1 activity using natural polysaccharide glycyrrhizin for successful outcome of islet transplantation
한국고분자학회 학술대회 연구논문 초록집
2015 .10
-
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3
Experimental and Molecular Medicine
2021 .08
-
HMGB1 modulation using glycyrrhizin-chitosan bioconjugate for successful outcomes of transplanted pancreatic islets
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
Experimental and Molecular Medicine
2020 .10
-
공종별 수선비용 추계모델을 활용한 공동주택 장기수선충당금 적립금액 산정
KIEAE Journal
2016 .06
-
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
Experimental and Molecular Medicine
2019 .01
-
Characteristics of the Economic Repair Time of the Components in Public Rental Housing
KIEAE Journal
2015 .02
-
Probabilistic Repair Cost Simulation for RC Structures Repaired With Bacteria Coating Material Under Sulfate Attack
International Journal of Concrete Structures and Materials
2022 .05
-
Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity
Experimental and Molecular Medicine
2021 .09
-
SET7-mediated TIP60 methylation is essential for DNA double-strand break repair
BMB Reports
2022 .11
-
Ubiquitin E3 ligases in cancer: somatic mutation and amplification
BMB Reports
2023 .05
-
The Characteristics of the Repair Cost Distribution in Apartment Housing
KIEAE Journal
2015 .12
-
Study on Repair of SKD 61 Using Directed Energy Deposition with H13 and P21 Powders
Journal of the Korean Society for Precision Engineering
2024 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0