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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 43 - 48 (6page)
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Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified agedependent macrophage accumulation in the bone marrow, showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10. BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and therapeutic clues.
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참고문헌 (28)
참고문헌 신청
Ainhoa Mielgo / 2013 / Impact of tumour associated macrophages in pancreatic cancer / BMB Reports 46 (3) : 131 ~ 138
Amano SU / 2014 / Local proliferation of macrophages contributes to obesityassociated adipose tissue inflammation / Cell Metab 19 : 162 ~ 171
Amir O / 2012 / Changes in the monocytic subsets CD14(dim)CD16(+) and CD14(++)CD16(-) in chronic systolic heart failure patients / Mediators Inflamm 2012 : 616384 ~
Arandjelovic S / 2015 / Phagocytosis of apoptotic cells in homeostasis / Nat Immunol 16 : 907 ~ 917
Ghesquiere B / 2014 / Metabolism of stromal and immune cells in health and disease / Nature 511 : 167 ~ 176
Amano SU / 2014 / Local proliferation of macrophages contributes to obesityassociated adipose tissue inflammation / Cell Metab 19 : 162 ~ 171
Amir O / 2012 / Changes in the monocytic subsets CD14(dim)CD16(+) and CD14(++)CD16(-) in chronic systolic heart failure patients / Mediators Inflamm 2012 : 616384 ~
Arandjelovic S / 2015 / Phagocytosis of apoptotic cells in homeostasis / Nat Immunol 16 : 907 ~ 917
Ghesquiere B / 2014 / Metabolism of stromal and immune cells in health and disease / Nature 511 : 167 ~ 176
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