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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 11 (11page)
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Spermatogonial stem cells (SSCs) are germline stem cells located along the basement membrane of seminiferous tubules in testes. Recently, SSCs were shown to be reprogrammed into multipotent SSCs (mSSCs). However, both the key factors and biological networks underlying this reprogramming remain elusive. Here, we present transcriptional regulatory networks (TRNs) that control cellular processes related to the SSC-to-mSSC reprogramming. Previously, we established intermediate SSCs (iSSCs) undergoing the transition to mSSCs and generated gene expression profiles of SSCs, iSSCs and mSSCs. By comparing these profiles, we identified 2643 genes that were up-regulated during the reprogramming process and 15 key transcription factors (TFs) that regulate these genes. Using the TF-target relationships, we developed TRNs describing how these TFs regulate three pluripotency-related processes (cell proliferation, stem cell maintenance and epigenetic regulation) during the reprogramming. The TRNs showed that 4 of the 15 TFs (Oct4/Pou5f1, Cux1, Zfp143 and E2f4) regulated cell proliferation during the early stages of reprogramming, whereas 11 TFs (Oct4/Pou5f1, Foxm1, Cux1, Zfp143, Trp53, E2f4, Esrrb, Nfyb, Nanog, Sox2 and Klf4) regulated the three pluripotency-related processes during the late stages of reprogramming. Our TRNs provide a model for the temporally coordinated transcriptional regulation of pluripotency-related processes during the SSC-to-mSSC reprogramming, which can be further tested in detailed functional studies.
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참고문헌 (27)
참고문헌 신청
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19 : 185 ~ 193
Brown KR / 2005 / Online predicted human intera
Chatr-aryamontri A / 2007 / MINT: the Molecular INTeraction database / Nucleic Acids Res 35 : D572 ~ D574
Conrad S / 2008 / Generation of pluripotent stem cells from adult human testis / Nature 456 : 344 ~ 349
Ekins S / 2007 / Pathway mapping tools for analysis of high content data / Methods Mol Biol 356 : 319 ~ 350
Brown KR / 2005 / Online predicted human intera
Chatr-aryamontri A / 2007 / MINT: the Molecular INTeraction database / Nucleic Acids Res 35 : D572 ~ D574
Conrad S / 2008 / Generation of pluripotent stem cells from adult human testis / Nature 456 : 344 ~ 349
Ekins S / 2007 / Pathway mapping tools for analysis of high content data / Methods Mol Biol 356 : 319 ~ 350
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