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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제6호
- 발행연도
- 2020.1
- 수록면
- 793 - 803 (11page)
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초록· 키워드
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Adaptive laboratory evolution (ALE) is an evolutionary engineering approach in artificial conditions that improves organisms through the imitation of natural evolution. Due to the development of multi-level omics technologies in recent decades, ALE can be performed for various purposes at the laboratory level. This review delineates the basics of the experimental design of ALE based on several ALE studies of industrial microbial strains and updates current strategies combined with progressed metabolic engineering, in silico modeling and automation to maximize the evolution efficiency. Moreover, the review sheds light on the applicability of ALE as a strain development approach that complies with non-recombinant preferences in various food industries. Overall, recent progress in the utilization of ALE for strain development leading to successful industrialization is discussed.
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등록된 정보가 없습니다.
참고문헌 (130)
참고문헌 신청
Phaneuf PV / 2019 / ALEdb 1.0: a database of mutations from adaptive laboratory evolution experimentation / Nucleic Acids Res. 47:D1164~D1171
Shepelin D / 2018 / Selecting the best : evolutionary engineering of chemical production in microbes / Genes(Basel) 9:249
Bennett AF / 2009 / Microbial experimental evolution 297:R17~R25
Kering KK / 2020 / Application of adaptive evolution to improve the stability of bacteriophages during storage / Viruses 12:E423
Bailey LA / 2012 / Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture / Biotechnol. Bioeng 109:2093~2103
Shepelin D / 2018 / Selecting the best : evolutionary engineering of chemical production in microbes / Genes(Basel) 9:249
Bennett AF / 2009 / Microbial experimental evolution 297:R17~R25
Kering KK / 2020 / Application of adaptive evolution to improve the stability of bacteriophages during storage / Viruses 12:E423
Bailey LA / 2012 / Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture / Biotechnol. Bioeng 109:2093~2103
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