지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제1호
- 발행연도
- 2020.1
- 수록면
- 107 - 113 (7page)
이용수
초록· 키워드
오류제보하기
system does not guarantee the stability of vaccines always and requires a high cost. Although solidification of vaccine can be alternative, vaccine stability is a problem. Recently, influenza vaccine delivery using microneedle formulation has been studied extensively. Moreover, the stability of the vaccine can be improved since the vaccine is solid form in the microneedle. Therefore, the aim of this study is to screen the suitable stabilizer in the drying process and to compare evaluation methods for H3N2 split vaccine stability. Methods Dried vaccine samples were evaluated by enzyme-linked immunosorbent assay (ELISA), sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and circular dichroism (CD). Results Fructose provided stability to the vaccine during the drying process by ELISA (91.1 ± 8.9%) and SDS-PAGE (about 65%). Trehalose was rated as providing stability to the vaccine when evaluated with ELISA and SDS-PAGE but was not when evaluated with CD. Conclusions The stability of the vaccine should be finally determined by comprehensively evaluating the structure and antigenicity of various proteins.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Amorij J / 2008 / Development of stable influenza vaccine powder formulations : challenges and possibilities / Pharm Res 25:1256~1273
Arakawa T / 2001 / Factors affecting short-term and long-term stabilities of proteins / Adv Drug Deliv Rev 46:307~326
Birchall JC / 2011 / Microneedles in clinical practice–an exploratory study into the opinions of healthcare professionals and the public / Pharm Res 28:95~106
Chu LY / 2016 / Enhanced stability of inactivated influenza vaccine encapsulated in dissolving microneedle patches / Pharm Res 33:868~878
Cicerone MT / 2004 / Fast dynamics and stabilization of proteins : binary glasses of trehalose and glycerol / Biophys J 86:3836~3845
Arakawa T / 2001 / Factors affecting short-term and long-term stabilities of proteins / Adv Drug Deliv Rev 46:307~326
Birchall JC / 2011 / Microneedles in clinical practice–an exploratory study into the opinions of healthcare professionals and the public / Pharm Res 28:95~106
Chu LY / 2016 / Enhanced stability of inactivated influenza vaccine encapsulated in dissolving microneedle patches / Pharm Res 33:868~878
Cicerone MT / 2004 / Fast dynamics and stabilization of proteins : binary glasses of trehalose and glycerol / Biophys J 86:3836~3845
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Should the COVID-19 Vaccine be Administered Simultaneously with Other Vaccines?
Infection and Chemotherapy
2021 .09
-
Exploring the experience of developing COVID-19 vaccines in Iran
Clinical and Experimental Vaccine Research
2023 .01
-
Vaccines in the United States: a systematic review on history of evolution, regulations, licensing, and future challenges
Clinical and Experimental Vaccine Research
2020 .01
-
Review of COVID-19 Vaccines and Their Evidence in Older Adults
Annals of geriatric medicine and research
2021 .01
-
Influenza Vaccine Effectiveness among Elementary School Students in Korea during the 2016-2017 Seasons: a Cross-Sectional Survey
Journal of Korean Medical Science
2020 .01
-
Therapeutic Vaccines and Nucleic Acid Drugs for Cardiovascular Disease
지질·동맥경화학회지
2024 .09
-
Ongoing Clinical Trials of Vaccines to Fight against COVID-19 Pandemic
Immune Network
2021 .02
-
Evaluation of stockpiled emergency vaccines for Foot-and-Mouth Disease in Korea, 2019-2021
예방수의학회지
2022 .12
-
Parenteral, non-live rotavirus vaccine: recent history and future perspective
Clinical and Experimental Vaccine Research
2021 .09
-
The Characteristics of RNA Vaccine
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Recent advances in nano/microparticle-based oral vaccines
Journal of Pharmaceutical Investigation
2021 .01
-
Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination
Allergy, Asthma & Immunology Research
2020 .01
-
Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines
Immune Network
2024 .06
-
Current development of therapeutic vaccines for the treatment of chronic infectious diseases
Clinical and Experimental Vaccine Research
2024 .01
-
Advancements in Cancer Immunotherapy: The Evolution and Future of mRNA and DNA Vaccine Technologies
대한의생명과학회지
2025 .03
-
Development of Actinobacillus pleuropneumoniae ApxI, ApxII, and ApxIII-specific ELISA methods for evaluation of vaccine efficiency
Journal of Veterinary Science
2019 .03
-
Factors influencing acceptance of the COVID-19 vaccine in Malaysia: a web-based survey
Osong Public Health and Research Persptectives
2021 .12
-
Automatic Stabilizers for Excess Vaccine Stockpiles: Responsibility and Vaccine Equity in an Age of Pandemics
보건학논집
2021 .12
-
Comparison of COVID-19 Vaccines Introduced in Korea
대한의생명과학회지
2022 .06
-
Mechanisms of Cross-protection by Influenza Virus M2-based Vaccines
Immune Network
2015 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0