지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 875 - 885 (11page)
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초록· 키워드
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BACKGROUND: Estrogen deficiency decreases bone density and increases the risk of osteoporosis and fracture, thereby necessitating reconstruction of bone regeneration. As bone marrow mesenchymal stem cell (BMSCs) lose viability and differentiation potential under osteoporotic conditions, it is impossible to use autologous BMSCs for osteoporosis treatment. As an alternative, adipose-derived stem cells (ADSCs) may serve as the source of therapeutic cells. METHOD: We evaluated the effects of osteoporosis on the functional characteristics of ADSCs. Osteoporosis was induced in ovariectomy (OVX) rat model, and the ADSCs from Sham and OVX groups were cultured and analyzed comparatively. RESULTS: As a result, the viability was higher for the ADSCs from Sham group than those from OVX group. The analysis of the paracrine potential of ADSCs revealed the elevated levels of inflammatory and cellular senescence factors in the ADSCs from OVX group. The ADSCs from OVX group had much higher differentiation potential into adipocytes than those from the Sham group. Osteoporotic environment had no effect on the osteogenic potential of ADSCs. CONCLUSION: Osteoporosis may reduce the activity and influence immune response of ADSCs by modulating paracrine action and adipogenic potential. These characteristics of ADSCs should be given consideration for therapeutic purpose.
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참고문헌 (37)
참고문헌 신청
Ji MX / 2015 / Primary osteoporosis in postmenopausal women / Chronic Dis Transl Med 1:9~13
Weitzmann MN / 2006 / Estrogen deficiency and bone loss : an inflammatory tale / J Clin Invest 116:1186~1194
Cenci S / 2003 / Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-y-induced class II transactivator / Proc Natl Acad Sci U S A 100:10405~10410
Cenci S / 2000 / Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha / J Clin Invest 106:1229~1237
Zheng SX / 1997 / Increase in cytokine production(IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF)by stimulated whole blood cells in postmenopausal osteoporosis / Maturitas 26:63~71
Weitzmann MN / 2006 / Estrogen deficiency and bone loss : an inflammatory tale / J Clin Invest 116:1186~1194
Cenci S / 2003 / Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-y-induced class II transactivator / Proc Natl Acad Sci U S A 100:10405~10410
Cenci S / 2000 / Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha / J Clin Invest 106:1229~1237
Zheng SX / 1997 / Increase in cytokine production(IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF)by stimulated whole blood cells in postmenopausal osteoporosis / Maturitas 26:63~71
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