지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 516 - 526 (11page)
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초록· 키워드
오류제보하기
For successful tissue engineering of articular cartilage, a scaffold with mechanical properties that match those of natural cartilage as closely as possible is needed. In the present study, we prepared a fibrous silk fibroin (SF)/poly(L-lactic acid) (PLLA) scaffold via electrospinning and investigated the morphological, mechanical, and degradation properties of the scaffolds fabricated using different electrospinning conditions, including collection distance, working voltage, and the SF:PLLA mass ratio. In addition, in vitro cell-scaffold interactions were evaluated in terms of chondrocyte adhesion to the scaffolds as well as the cytotoxicity and cytocompatibility of the scaffolds. The optimum electrospinning conditions for generating a fibrous SF/PLLA scaffold with the best surface morphology (ordered alignment and suitable diameter) and tensile strength (~1.5 MPa) were a collection distance of 20 cm, a working voltage of 15 kV, and a SF:PLLA mass ratio of S50P50. The degradation rate of the SF/PLLA scaffolds was found to be determined by the SF:PLLA mass ratio, and it could be increased by reducing the PLLA proportion. Furthermore, chondrocytes spread well on the fibrous SF/PLLA scaffolds and secreted extracellular matrix, indicating good adhesion to the scaffold. The cytotoxicity of SF/PLLA scaffold extract to chondrocytes over 24 and 48 h in culture was low, indicating that the SF/PLLA scaffolds are biocompatible. Chondrocytes grew well on the SF/PLLA scaffold after 1, 3, 5, and 7 days of direct contact, indicating the good cytocompatibility of the scaffold. These results demonstrate that the fibrous SF/PLLA scaffold represents a promising composite material for use in cartilage tissue engineering.
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참고문헌 (42)
참고문헌 신청
Klein J / 2009 / Chemistry. Repair or replacement--a joint perspective / Science 323:47~48
Zhang HY / 2008 / Femoral stem wear in cemented total hip replacement / Proc Inst Mech Eng H 222:583~592
Dowson D / 2012 / Bio-tribology / Faraday Discuss 156:9~103
Liao Y / 2011 / Graphitic tribological layers in metal-on-metal hip replacements / Science 334:1687~1690
Zhang H / 2009 / Understanding initiation and propagation of fretting wear on the femoral stem in total hip replacement / Wear 266:566~569
Zhang HY / 2008 / Femoral stem wear in cemented total hip replacement / Proc Inst Mech Eng H 222:583~592
Dowson D / 2012 / Bio-tribology / Faraday Discuss 156:9~103
Liao Y / 2011 / Graphitic tribological layers in metal-on-metal hip replacements / Science 334:1687~1690
Zhang H / 2009 / Understanding initiation and propagation of fretting wear on the femoral stem in total hip replacement / Wear 266:566~569
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