지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1 - 13 (13page)
- DOI
- 10.1038/s12276-021-00670-3
이용수
초록· 키워드
오류제보하기
PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of relevant anticancer agents. TGF-β plays an important role in the low reactivity of PD-1/PD-L1 antibody immunotherapy. However, it is not very clear whether and how TGF-β affects PD-L1 expression. In the present study, we show that TGF-β upregulates the expression of the transcriptional coactivator MRTF-A in non-small-cell lung cancer cells, which subsequently interacts with NF-κB/p65 rather than SRF to facilitate the binding of NF-κB/p65 to the PDL1 promoter, thereby activating the transcription and expression of PD-L1. This leads to the immune escape of NSCLC cells. This process is dependent on the activation of the TGF-β signaling pathway. In vivo, inhibition of MRTF-A effectively suppresses the growth of lung tumor s y ngrafts with enrichment of NK and T cells in tumor tissue. Our study defines a new signaling pathway that regulates the transcription and expression of PD-L1 upon TGF-β treatment, which may have a significant impact on research into the application of immunotherapy in treating lung cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
Experimental and Molecular Medicine
2019 .01
-
PD에게 5G란 무엇인가?
방송과 미디어
2019 .07
-
Development of Human PD-1 Specific Repebody for Cancer Immunotherapy
한국생물공학회 학술대회
2019 .04
-
Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity
BMB Reports
2021 .01
-
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells
Experimental and Molecular Medicine
2021 .05
-
TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model
Experimental and Molecular Medicine
2017 .01
-
Amorphous Co3O4-Decorated Pd as an Efficient Electrocatalyst for Methanol Oxidation
NANO
2017 .01
-
Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail
BMB Reports
2017 .01
-
T Cell-derived Nanovesicles for Cancer Immunotherapy
한국생물공학회 학술대회
2021 .10
-
Improvement of Human Transforming Growth Factor-β1 Expression in Chinese Hamster Ovary Cells by Post-transcriptional Regulation Element
한국생물공학회 학술대회
2021 .10
-
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
Experimental and Molecular Medicine
2020 .09
-
폐촉매로부터 Pd회수 및 이를 이용한 Pd/C 촉매 재제조 기술 개발
공업화학
2018 .01
-
Features Extraction and Mechanism Analysis of Partial Discharge Development under Protrusion Defect
Journal of Electrical Engineering & Technology
2015 .01
-
An Avidity-Based PD-L1 Receptor for the Highly Sensitive Isolation of Circulating Tumor Cells: Accurate Prediction of Immunotherapy Response
한국생물공학회 학술대회
2024 .09
-
PD 및 신경망 알고리즘을 이용한 비선형 시스템 제어
한국정밀공학회 학술발표대회 논문집
2016 .10
-
조선해양PD를 마치면서
대한조선학회지
2021 .06
-
TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13
조직공학과 재생의학
2021 .10
-
Colorimetric Sensor Based on Pd–MoO3 Nanowires for Hydrogen Gas Leak Detection
센서학회지
2024 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0