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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1 - 10 (10page)
- DOI
- 10.1186/s40580-021-00285-4
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초록· 키워드
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Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating human kidney are the attractive tool for kidney regeneration, disease modeling, and drug screening. However, the kidney organoids cultured by static conditions have the limited vascular networks and immature nephron-like structures unlike human kidney. Here, we developed a kidney organoid-on-a-chip system providing fluidic flow mimicking shear stress with optimized extracellular matrix (ECM) conditions. We demonstrated that the kidney organoids cultured in our microfluidic system showed more matured podocytes and vascular structures as compared to the static culture condition. Additionally, the kidney organoids cultured in microfluidic systems showed higher sensitivity to nephrotoxic drugs as compared with those cultured in static conditions. We also demonstrated that the physiological flow played an important role in maintaining a number of physiological functions of kidney organoids. Therefore, our kidney organoid-on-a-chip system could provide an organoid culture platform for in vitro vascularization in formation of functional three-dimensional (3D) tissues.
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참고문헌 (50)
참고문헌 신청
J. V. Bonventre / 2010 / Nat. Biotechnol 28:436
M. W. van der Helm / 2016 / Tissue Barriers 4:e1142493
M. Hofer / 2021 / Nat. Rev. Mater 6:402
T. Sato / 2009 / Nature 459:262
Mun Seok Gyu / 2020 / rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform / Nano Convergence 7(10):1~11
M. W. van der Helm / 2016 / Tissue Barriers 4:e1142493
M. Hofer / 2021 / Nat. Rev. Mater 6:402
T. Sato / 2009 / Nature 459:262
Mun Seok Gyu / 2020 / rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform / Nano Convergence 7(10):1~11
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