Progress and challenges of the bioartificial pancreas

Hwang Patrick T. J.; Shah Dishant K.; Garcia Jacob A.; Bae Chae Yun; Lim Dong-Jin; Huiszoon Ryan C.; Alexander Grant C.; Jun Ho-Wook

doi:10.1186/s40580-016-0088-4

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자료유형: 학술저널

저자정보: Hwang Patrick T. J. (University of Alabama at Birmingham) Shah Dishant K. (University of Alabama at Birmingham) Garcia Jacob A. (University of Alabama at Birmingham) Bae Chae Yun (University of Alabama at Birmingham) Lim Dong-Jin (University of Alabama at Birmingham) Huiszoon Ryan C. (University of Alabama at Birmingham) Alexander Grant C. (University of Alabama at Birmingham) Jun Ho-Wook (University of Alabama at Birmingham)

저널정보: 나노기술연구협의회 Nano Convergence Nano Convergence Vol.3 No.28

발행연도: 2016.11

수록면: 1 - 11 (11page)

DOI: 10.1186/s40580-016-0088-4

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Pancreatic islet transplantation has been validated as a treatment for type 1 diabetes since it maintains consistent and sustained type 1 diabetes reversal. However, one of the major challenges in pancreatic islet transplantation is the body’s natural immune response to the implanted islets. Immunosuppressive drug treatment is the most popular immunomodulatory approach for islet graft survival. However, administration of immunosuppressive drugs gives rise to negative side effects, and long-term effects are not clearly understood. A bioartificial pancreas is a therapeutic approach to enable pancreatic islet transplantation without or with minimal immune suppression. The bioartificial pancreas encapsulates the pancreatic islets in a semi-permeable environment which protects islets from the body’s immune responses, while allowing the permeation of insulin, oxygen, nutrients, and waste. Many groups have developed various types of the bioartificial pancreas and tested their efficacy in animal models. However, the clinical application of the bioartificial pancreas still requires further investigation. In this review, we discuss several types of bioartificial pancreases and address their advantages and limitations. We also discuss recent advances in bioartificial pancreas applications with microfluidic or micropatterning technology.

#Bioartificial pancreas Macroencapsulation Microencapsulation Islet surface modification Microfluidic Micropatterning

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참고문헌 신청

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K.W. Kim / 2004 / Diabetes Res Clin Pract 66(Suppl 1):S11

R. P. Robertson / 2004 / J Med 350:694

R. F. Gibly / 2011 / Diabetologia 54:2494

M. A. Kanak / 2014 / Int J Endocrinol 2014:451035

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