지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.4
- 수록면
- 63 - 72 (10page)
- DOI
- 10.7783/KJMCS.2024.32.2.63
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초록· 키워드
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Background: Hippophae rhamnoides is a medicinal plant and potential functional food component. To date, leaf and fruit mixtures have not been studied for immune-enhancing effects. We herein examined these mixtures for such effects.
Methods and Results: An H. rhamnoides leaf and fruit mixture (HLF) was orally administered for 4 weeks to experimental male mice in normal and cyclophosphamide-induced immunosuppressed states, and biomarkers indicating immunomodulation were measured. In immunosuppressed animals, 200 ㎎/㎏ HLF significantly increased the serum tumor necrosis factor-α levels. B cell proliferation in the spleen upon activation by lipopolysaccharide treatment was also examined and found to be significantly lower in the immunosuppressed group than in the normal control group. Administration of HLF (100 and 200 ㎎/㎏) significantly increased cell proliferation. T cell proliferation in the spleen upon activation with concanavalin A was significantly increased by HLF in both normal and immunosuppressed animals. HLF also decreased the production and secretion of the pro-inflammatory cytokine interleukin (IL)-2, and increased production of the antiinflammatory cytokine IL-6 in splenocytes.
Conclusions: HLF administration enhances immune function in normal mice and regulates the immune system in immunocompromised mice.
Methods and Results: An H. rhamnoides leaf and fruit mixture (HLF) was orally administered for 4 weeks to experimental male mice in normal and cyclophosphamide-induced immunosuppressed states, and biomarkers indicating immunomodulation were measured. In immunosuppressed animals, 200 ㎎/㎏ HLF significantly increased the serum tumor necrosis factor-α levels. B cell proliferation in the spleen upon activation by lipopolysaccharide treatment was also examined and found to be significantly lower in the immunosuppressed group than in the normal control group. Administration of HLF (100 and 200 ㎎/㎏) significantly increased cell proliferation. T cell proliferation in the spleen upon activation with concanavalin A was significantly increased by HLF in both normal and immunosuppressed animals. HLF also decreased the production and secretion of the pro-inflammatory cytokine interleukin (IL)-2, and increased production of the antiinflammatory cytokine IL-6 in splenocytes.
Conclusions: HLF administration enhances immune function in normal mice and regulates the immune system in immunocompromised mice.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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