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논문 기본 정보

자료유형
학술저널
저자정보
Jeong Sung Hoon (Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Korea.Institute of Health Services Research, Yonsei University, Seoul, Korea.Department of Rehabilitation Me) Hurh Kyungduk (Institute of Health Services Research, Yonsei University, Seoul, Korea.Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.) Park Eun-Cheol (Institute of Health Services Research, Yonsei University, Seoul, Korea.Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.) Leigh Ja-ho (Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Korea.Department of Rehabilitation Medicine, National Traffic Injury Rehabilitation Hospital, Yangpyeong, Ko) Kim Seung Hoon (Institute of Health Services Research, Yonsei University, Seoul, Korea.Department of Preventive Medicine, Eulji University School of Medicine, Daejeon, Korea.) Jang Sung-In (Institute of Health Services Research, Yonsei University, Seoul, Korea.Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.4
발행연도
2024.1
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2024.39.e21

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초록· 키워드

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Background: Acute pancreatitis may increase the risk of pancreatic cancer, although this association remains unclear. Therefore, we aimed to investigate this association. Methods: We retrospectively analyzed the 2002–2019 Korean National Health Insurance ServiceNational Sample Cohort using 1:3 propensity score matching for sex and age (acute pancreatitis, n = 4,494; matched controls, n = 13,482). We calculated the hazard ratio (HR) for pancreatic cancer risk in patients with acute pancreatitis using Cox proportional hazards regression. Results: Acute pancreatitis was significantly associated with an increased risk of pancreatic cancer throughout the study period (adjusted HR, 7.56 [95% confidence interval, 5.00– 11.41]), which persisted for 2, 2–5, and > 5 years post-diagnosis (19.11 [9.60–38.05], 3.46 [1.35–8.33], and 2.73 [1.21–6.15], respectively). This pancreatitis-related pancreatic cancer risk became insignificant beyond 10 years of follow-up (1.24 [0.24–6.49]). Furthermore, this risk notably increased as the number of recurrent acute pancreatitis episodes increased (1 episode: 5.25 [3.31–8.33], 2 episodes: 11.35 [6.38–20.19], ≥ 3 episodes: 24.58 [13.66–44.26]). Conclusion: Following an acute pancreatitis diagnosis, the risk of pancreatic cancer increases significantly in the initial years, with a rapid increase further accentuated with recurrent acute pancreatitis episodes. Additional study is needed to evaluate whether this increased risk of carcinogenesis is attributed to accumulated inflammation.

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