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학술저널
저자정보
박소현 (국립암센터 핵의학과) 정아리 (조선대학교) 강호철 (전남대학교) 김근영 (부산대학교) 김선욱 (성균관대학교) 나동규 (분당서울대학교병원) 박영주 (서울대학교) 방지인 (차의과학대학교 분당차병원) 서영덕 (세종충남대학교병원) 송영신 (서울특별시보라매병원) 오소원 (서울대학교) 이은경 (국립암센터) 임동준 (가톨릭대학교) 정윤재 (중앙대학교) 홍채문 (경북대학교) 이상우 (경북대학교)
저널정보
대한갑상선학회 International Journal of Thyroidology International Journal of Thyroidology 제17권 제1호
발행연도
2024.5
수록면
97 - 110 (14page)

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The initial treatment for differentiated thyroid cancer includes appropriate surgery and radioactive iodine (RAI) therapy, followed by thyroid-stimulating hormone (TSH) suppression therapy as long-term management to prevent recurrence. RAI therapy following thyroidectomy has the three main purposes: remnant ablation, adjuvant therapy, and therapy for known disease. To optimize the goals and targets of RAI therapy, postoperative disease assessment, determination of recurrence risk, and consideration of various individual factors are necessary. The objectives of RAI therapy are determined based on the individual’s recurrence risk, and the administered activity of RAI is then determined according to these treatment objectives. Adequate stimulation of serum TSH is necessary before RAI therapy, and recombinant human TSH is widely used because of its advantage in reducing the risk of exacerbation of comorbidities associated with levothyroxine discontinuation and improving patients’ quality of life. Additionally, reducing iodine intake through appropriate low-iodine diet is necessary. Whole-body scans are conducted to assess the disease status after RAI therapy. If planar whole-body scans are inconclusive, additional single-photon emission computed tomography (SPECT)/CT imaging is recommended. Over the past decade, prospective randomized or retrospective clinical studies on the selection of candidates for RAI therapy, administered activity, methods of TSH stimulation, and advantages of SPECT/CT have been published. Based on these latest clinical research findings and recommendations from relevant overseas medical societies, this clinical practice guideline presents the indications and methods for administering RAI therapy after thyroidectomy.

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