지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 199 - 206 (8page)
- DOI
- 10.7841/ksbbj.2019.34.3.199
이용수
초록· 키워드
오류제보하기
Collagen is decomposed by MMP-1, an enzyme induced by transcription factor activator protein 1 (AP-1) and matrix metalloproteinase-9 (MMP-9). Action of MMPs in inflammatory response promotes inflammatory cell movement and secretion, resulting in wrinkles on the skin. After using Bacillus sp. fermentation system and water, Artemisia vulgaris was fermented to prepare different solvent fractions using water, dichloromethane, hex ane, n-butanol, and ethyl acetate. These fractions were used to assess their effects on cell survival, wound healing, MMP-1/MMP-9 and procollagen type I C-peptide (PICP) expression, and skin turnover. MTT assay showed that cell viability of each treated group was 103% to 121%, indicating that A. vulgaris fractions were not toxic compared to control (cell viability: 100%). Wound healing assay revealed that wound healing ability in each treated group was 51% to 61%. This was lower than wound healing area in the control. Using RT-PCR, inhibition of MMP-1/MMP-9 gene expression was examined. As a result, each group treated with fraction showed reduced expression of both MMP-1 and MMP-9 compared to tumor necrosis factor-α (TNF-α) treatment group. Effects on collagen biosynthesis were analyzed using a PICP ELISA Kit. The group in which Artemisia vulgaris was treated increased collagen synthesis from 141 to 262ng/mL compared to the control group. Three-dimensional cell culture revealed that each fraction could increase skin wall formation. These results suggest that each fractions has anti-aging and anti-wrinkle effects on the skin, indicating its suitability as a functional material.
목차
Abstract
1. INTRODUCTION
2. MATERIALS and METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCE
참고문헌 (32)
참고문헌 신청
Puizina-Ivic, N. / 2008 / Skin aging / Acta. Dermatovenerol.Alp. Pannonica. Adriat 17:47~54
Tobin, D. J. / 2017 / Introduction to skin aging / J. Tissue Viability 26:37~46
Farage, M. A. / 2008 / Intrinsic and extrinsic factors in skin ageing: a review / Int. J. Cosmet. Sci 30:87~95
Pillai, S. / 2005 / Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation? induced matrix degradation–a review / Int. J. Cosmet. Sci 27:17~34
Dhar, A. / 2002 / The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive / Mol. Cell Biochem 234:185~193
Tobin, D. J. / 2017 / Introduction to skin aging / J. Tissue Viability 26:37~46
Farage, M. A. / 2008 / Intrinsic and extrinsic factors in skin ageing: a review / Int. J. Cosmet. Sci 30:87~95
Pillai, S. / 2005 / Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation? induced matrix degradation–a review / Int. J. Cosmet. Sci 27:17~34
Dhar, A. / 2002 / The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive / Mol. Cell Biochem 234:185~193
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UCI(KEPA) : I410-ECN-0101-2019-470-001230272