지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 580 - 590 (11page)
- DOI
- 10.14348/molcells.2021.0101
이용수
초록· 키워드
오류제보하기
Patients with severe asthma have unmet clinical needs for effective and safe therapies. One possibility may be mesenchymal stem cell (MSC) therapy, which can improve asthma in murine models. However, it remains unclear how MSCs exert their beneficial effects in asthma. Here, we examined the effect of human umbilical cord blood-derived MSCs (hUC-MSC) on two mouse models of severe asthma, namely, Alternaria alternata-induced and house dust mite (HDM)/diesel exhaust particle (DEP)-induced asthma. hUCMSC treatment attenuated lung type 2 (Th2 and type 2 innate lymphoid cell) inflammation in both models. However, these effects were only observed with particular treatment routes and timings. In vitro co-culture showed that hUCMSC directly downregulated the interleukin (IL)-5 and IL-13 production of differentiated mouse Th2 cells and peripheral blood mononuclear cells from asthma patients. Thus, these results showed that hUC-MSC treatment can ameliorate asthma by suppressing the asthmogenic cytokine production of effector cells. However, the successful clinical application of MSCs in the future is likely to require careful optimization of the route, dosage, and timing.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Castro, L. L. / 2020 / Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma / Stem Cells Transl. Med 9:250~260
Sung-Whan Kim / 2021 / Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis / Molecules and Cells 44(4):245~253
Court, A. C. / 2020 / Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response / EMBO Rep 21:e48052
Cruz, F. F. / 2015 / Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extractinduced allergic airway inflammation in immunocompetent mice / Stem Cells Transl. Med 4:1302~1316
de Castro, L. L. / 2017 / Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma / Stem Cell Res. Ther 8:151
Sung-Whan Kim / 2021 / Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis / Molecules and Cells 44(4):245~253
Court, A. C. / 2020 / Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response / EMBO Rep 21:e48052
Cruz, F. F. / 2015 / Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extractinduced allergic airway inflammation in immunocompetent mice / Stem Cells Transl. Med 4:1302~1316
de Castro, L. L. / 2017 / Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma / Stem Cell Res. Ther 8:151
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Intravenous Mesenchymal Stem Cell Administration Modulates Monocytes/Macrophages and Ameliorates Asthmatic Airway Inflammation in a Murine Asthma Model
Molecules and Cells
2022 .11
-
The Role of the Microbiota in Asthma
한국미생물학회 학술대회논문집
2015 .04
-
Effects of Adenoviral Gene Transduction on the Stemness of Human Bone Marrow Mesenchymal Stem Cells
Molecules and Cells
2017 .08
-
Immune Modulatory Effects of Mesenchymal Stem Cells Mediated by Lymphocyte Recruitment
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .06
-
Exploring the Association between Microbiome and Asthma
한국미생물학회 학술대회논문집
2022 .10
-
Attenuation of Postischemic Genomic Alteration by Mesenchymal Stem Cells: a Microarray Study
Molecules and Cells
2016 .04
-
Role of lymphoid lineage cells aberrantly expressing alarmins S100A8/A9 in determining the severity of COVID-19
Genes & Genomics
2023 .03
-
Global proteomic analysis of mesenchymal stem cells derived from human embryonic stem cells via connective tissue growth factor treatment under chemically defined feeder-free culture conditions
Journal of Microbiology and Biotechnology
2022 .01
-
Gene Profiles in a Smoke-Induced COPD Mouse Lung Model Following Treatment with Mesenchy-mal Stem Cells
Molecules and Cells
2016 .10
-
Microarray analysis after adipose derived mesenchymal stem cells injection in monosodium iodoacetate-induced osteoarthritis rats
Genes & Genomics
2018 .01
-
Metabolomic approaches to monitoring of biomarkers in asthma mouse model
한국분석과학회 학술대회
2018 .05
-
Microbiota Shape the Function of Innate Lymphoid Cells
한국미생물학회 학술대회논문집
2017 .04
-
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan
Molecules and Cells
2018 .03
-
Associations of dietary vitamin A and C intake with asthma, allergic rhinitis, and allergic respiratory diseases
Nutrition Research and Practice
2023 .10
-
Associations of dietary vitamin A and C intake with asthma, allergic rhinitis, and allergic respiratory diseases
Nutrition Research and Practice
2023 .10
-
공간적 관계를 고려한 천식과 미세먼지의 패턴 분석
한국데이터정보과학회지
2024 .07
-
해조류 유래 호흡기 질환 천식 치료제 연구 동향
한국해양바이오학회지
2020 .06
-
중간엽줄기세포(MSC)를 이용한 허혈성 혈관질환 치료를 위한 세포치료제 개발: 기초연구에서 임상연구
생명과학회지
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0