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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 549 - 558 (10page)
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초록· 키워드
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Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.
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참고문헌 (99)
참고문헌 신청
Berneburg M / 2006 / 'To repair or not to repair - no longer a question':repair of mitochondrial DNA shielding against age and cancer / Exp Dermatol 15:1005~1015
He X / 2013 / Suppression of mitochondrial complex I influences cell metastatic properties / PLoS One 8:e61677
Boiteux S / 2000 / The human OGG1gene: structure, functions, and its implication in the process of carcinogenesis / Arch Biochem Biophys 377:1~8
Brandon M / 2006 / Mitochondrial mutations in cancer / Oncogene 25:4647~4662
Zhang YQ / 2008 / Expression and modification of ARC(apoptosis repressor with a CARD domain)is distinctly regulated by oxidative stress in cancer cells / J Cell Biochem 104:818~825
He X / 2013 / Suppression of mitochondrial complex I influences cell metastatic properties / PLoS One 8:e61677
Boiteux S / 2000 / The human OGG1gene: structure, functions, and its implication in the process of carcinogenesis / Arch Biochem Biophys 377:1~8
Brandon M / 2006 / Mitochondrial mutations in cancer / Oncogene 25:4647~4662
Zhang YQ / 2008 / Expression and modification of ARC(apoptosis repressor with a CARD domain)is distinctly regulated by oxidative stress in cancer cells / J Cell Biochem 104:818~825
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