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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 2 (2page)
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Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologies and diseases. In contrast to replicative senescence, premature senescence could be rapidly induced through intrinsic and extrinsic insults. Cancer cell senescence has been accepted as an alternative and attractive tumor suppressive mechanism. In addition to the non-proliferative aspect, senescence associated with diverse functionality affects tissue homeostasis through the communication with their neighboring cells. Aging is a time-dependent process of deterioration, accompanied by progressive metabolic alteration and accumulation of senescent cells. Thus, aging is the main risk factor for many chronic diseases. Chronic inflammation which is principally induced by senescence associated secretory phenotype (SASP) might be the major underlying cause of many age-related disease. Recently, senotherapeutics, medicines targeting to kill or modulate senescent cells selectively, have been implicated to be novel strategy for aging intervention which is applicable to promote healthy aging and to prevent or treat age-related diseases. This special issue invites one perspective and ten mini-reviews covering various senescence features, gene expression characteristics with aging, therapeutic strategies related with cancer and age-related diseases.
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Cellular senescence: a promising strategy for cancer therapy
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From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
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MicroRNA controls of cellular senescence
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Juxtacrine regulation of cellular senescence
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Metabolic features and regulation in cell senescence
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Cellular senescence in cancer
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Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
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Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
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Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues
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Annexin A2 as a regulator of the cellular senescence and apoptosis through p21
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Alternative Polyadenylation(APA)-mediated 3’UTR Lengthening Contributes to Cellular Senescence
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Links between accelerated replicative cellular senescence and down-regulation of SPHK1 transcription
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Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
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Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
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Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss
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Senescent tumor cells: an overlooked adversary in the battle against cancer
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TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency
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Adiponectin Induces the Age-related Salivary Gland Lipid Accumulation
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Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence
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