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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 42 - 46 (5page)
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Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues’ microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.
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참고문헌 (59)
참고문헌 신청
Hayflick L / 1961 / The serial cultivation of human diploid cell strains / Exp Cell Res 25:585~621
Herbert B / 1999 / Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death / Proc Natl Acad Sci U S A 96:14276~14281
Baird DM / 2003 / Extensive allelic variation and ultrashort telomeres in senescent human cells / Nat Genet 33:203~207
Baerlocher GM / 2003 / Telomere shortening in leukocyte subpopulations from baboons / J Leukoc Biol 73:289~296
Lopez-Otin C / 2013 / The hallmarks of aging / Cell 153:1194~1217
Herbert B / 1999 / Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death / Proc Natl Acad Sci U S A 96:14276~14281
Baird DM / 2003 / Extensive allelic variation and ultrashort telomeres in senescent human cells / Nat Genet 33:203~207
Baerlocher GM / 2003 / Telomere shortening in leukocyte subpopulations from baboons / J Leukoc Biol 73:289~296
Lopez-Otin C / 2013 / The hallmarks of aging / Cell 153:1194~1217
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