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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 528 - 533 (6page)
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Peroxiredoxin I (Prx I) plays an important role as a reactive oxygen species (ROS) scavenger in protecting and maintaining cellular homeostasis; however, the underlying mechanisms are not well understood. Here, we identified a critical role of Prx I in protecting cells against ROS-mediated cellular senescence by suppression of p16INK4a expression. Compared to wild-type mouse embryonic fibroblasts (WT-MEFs), Prx I-/- MEFs exhibited senescence-associated phenotypes. Moreover, the aged Prx I-/- mice showed an increased number of cells with senescence associated-β-galactosidase (SA-β-gal) activity in a variety of tissues. Increased ROS levels and SA-β-gal activity, and reduction of chemical antioxidant further in Prx I-/- MEF supported an essential role of Prx I peroxidase activity in cellular senescence that is mediated by oxidative stress. The up-regulation of p16INK4a expression in Prx I-/- and suppression by overexpression of Prx I indicate that Prx I possibly modulate cellular senescence through ROS/p16INK4a pathway.
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참고문헌 (37)
참고문헌 신청
Turner-Ivey B / 2013 / Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer / Oncogene 32:5302~5314
Campisi J / 2005 / Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors / Cell 120:513~522
고아람 / 2016 / Dynamics of ARF regulation that control senescence and cancer / BMB Reports 49(11):598~606
Krtolica A / 2001 / Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging / Proc Natl Acad Sci U S A 98:12072~12077
Lawrenson K / 2010 / Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer / Neoplasia 12:317~325
Campisi J / 2005 / Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors / Cell 120:513~522
고아람 / 2016 / Dynamics of ARF regulation that control senescence and cancer / BMB Reports 49(11):598~606
Krtolica A / 2001 / Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging / Proc Natl Acad Sci U S A 98:12072~12077
Lawrenson K / 2010 / Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer / Neoplasia 12:317~325
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